A lower level of BEI was demonstrated in duodenal ulcer patients in both acute and chronic cases (P less than 0.01). Treatment of patients with PI increases BEI up to values found in healthy subjects, in accordance with our previous findings (17).
View Article and Find Full Text PDF335 general practitioners participated in an observational study of the alginic acid-containing antacid preparation Gaviscon over a period of eight months. In this period, 2927 patients with reflux disease were treated. Some 62.
View Article and Find Full Text PDFA lower level of beta-endorphin (BE) was demonstrated in patients with both acute and chronic duodenal ulcer (P less than 0.01), while the basal level of bombesin (BO) in such patients did not differ from that in healthy subjects. The basal pancreatic polypeptide (PP) level was higher in both groups of patients, primarily in those with acute ulcer (P less than 0.
View Article and Find Full Text PDFInt J Clin Pharmacol Ther Toxicol
May 1988
Despite the very high chemical similarity of pirenzepine (P) to the selected tricyclic antidepressive drugs (TCAD) (imipramine, desimipramine, nortriptyline and amitriptyline), P has a distinctly different effect on platelets, in particular, on serotonin uptake and platelet aggregation. Using two groups of nine healthy volunteers, mean age 27.7 and 27.
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