Publications by authors named "O Tabbene"
Article Synopsis
- This study evaluated the antioxidant and antileishmanial effects of essential oil from Ballota (B.) hirsuta leaves, identifying spathulenol and germacrene D as its main components.
- The essential oil demonstrated moderate antioxidant activity and high antileishmanial effectiveness against both promastigote and amastigote forms of Leishmania, with specific IC values indicating its potency.
- The study also revealed that B. hirsuta EO primarily inhibits the sterol synthesis pathway and suggested that its main compounds may be promising candidates for developing treatments against leishmaniasis.
As part of the development of alternative and environmentally friendly control against phytopathogenic fungi, could be a useful species notably via the generation of hydrolytic enzymes like chitinases, which can act as a biological control agent. Here, a S614 strain exhibiting chitinase activity was isolated from a soil in southern Tunisia. Then, response surface methodology (RSM) with a central composite design (CCD) was used to assess the impact of five factors (colloidal chitin, magnesium sulfate, dipotassium phosphate, yeast extract, and ammonium sulfate) on chitinase activity.
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- Antibiotic resistance and biofilm formation in Gram-negative bacteria pose significant challenges for infection control, particularly through the Quorum Sensing (QS) mechanism.
- Myrtle leaf extract demonstrated a potent anti-QS effect, inhibiting 80% of violacein production and significantly reducing various virulence factors like biofilm formation and protease activity at sub-MIC concentrations.
- The study identified three phenolic compounds from the extract, with 3,5-di-galloylquinic acid showing the strongest interaction with the CviR QS receptor, indicating potential for developing new QS inhibitors against resistant pathogens.
Article Synopsis
- * Major compounds identified in the EO included α-pinene and -cadinol, but the oil showed limited antioxidant activity, failing to neutralize certain free radicals effectively.
- * The EO demonstrated strong leishmanicidal effects against promastigote and amastigote forms, with the components showing better binding to the enzyme CYP51 compared to the conventional drug fluconazole, suggesting it could be a promising alternative treatment for leishmaniasis.
Aim: The present study aimed to investigate a novel antifungal compound produced by Streptomyces blastmyceticus S108 strain. Its effectiveness against clinical isolates of Candida species and its synergistic effect with conventional antifungal drugs were assessed, and its molecular mechanism of action was further studied against Candida albicans.
Methods And Results: A newly isolated strain from Tunisian soil, S.