Diversity of Structural, Dynamic, and Environmental Effects Explain a Distinctive Functional Role of Transmembrane Domains in the Insulin Receptor Subfamily.

Human InsR, IGF1R, and IRR receptor tyrosine kinases (RTK) of the insulin receptor subfamily play an important role in signaling pathways for a wide range of physiological processes and are directly associated with many pathologies, including neurodegenerative diseases. The disulfide-linked dimeric structure of these receptors is unique among RTKs. Sharing high sequence and structure homology, the receptors differ dramatically in their localization, expression, and functions.

Cytostatic effects of structurally different ginsenosides on yeast cells with altered sterol biosynthesis and transport.

Triterpene glycosides are a diverse group of plant secondary metabolites, consisting of a sterol-like aglycon and one or several sugar groups. A number of triterpene glycosides show membranolytic activity, and, therefore, are considered to be promising antimicrobial drugs. However, the interrelation between their structure, biological activities, and target membrane lipid composition remains elusive.

[The quality of life of patients after orthodontic treatment depending on the use of different types of retention appliances].

Aim: To assess the impact of the type of retention device on the quality of life of orthodontic patients.

Material And Methods: 311 patients were divided into four groups according to age. At the end of active orthodontic treatment, retainers were installed.

[Thyroid functional activity and hemodynamic parameters in upper-class schoolchildren presenting with endemic goiter].

We studied the relationship between iodine deficiency, blood cortisol levels, andhemodynamicparameters in 536schoolchildren of Vladikavkaz aged 13-17 years. Urine iodine was measured using cerium arsenite reaction, thyroid function was evaluated from thyrotropin, T3, and free T4 levels, blood cortisol was determined by the immonoenzyme assay using Alcor Bio kits. The study group included 24 subjects with endemic goiter, control group was comprised of 14 healthy adolescents.

[Epidemiological parameters in the evaluation of endemic goiter in the Republic of North Ossetia-Alania].

Aim: To study the incidence of endemic goiter among urban and rural schoolchildren in the Republic of North Ossetia-Alania (RNO-Alania).

Subjects And Methods: 1198 urban (637 girls and 561 boys) and 227 rural (137 girls and 90 boys) adolescents aged 13-16 years were examined. All the adolescents underwent thyroid palpation.