Publications by authors named "O T Akinniyi"

The role of the human ankle joint in activities of daily living, including walking, maintaining balance, and participating in sports, is of paramount importance. Ankle joint dorsiflexion and plantarflexion functionalities mainly account for ground clearance and propulsion power generation during locomotion tasks, where those functionalities are driven by the contraction of ankle joint skeleton muscles. Studies of corresponding muscle contractility during ankle dynamic functions will facilitate us to better understand the joint torque/power generation mechanism, better diagnose potential muscular disorders on the ankle joint, or better develop wearable assistive/rehabilitative robotic devices that assist in community ambulation.

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Yeast Def1 mediates RNA polymerase II degradation and transcription elongation during stress. Def1 is predominantly cytoplasmic, and DNA damage signals cause its proteolytic processing, liberating its N-terminus to enter the nucleus. Cytoplasmic functions for this abundant protein have not been identified.

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Background: The ability to respond effectively to balance perturbations is crucial for fall prevention. Subsensory electrical stimulation (SES) applied to the skin leads to improved proactive balance control but there is limited evidence on the SES effect on reactive balance control.

Research Questions: To test the efficiency of SES in improving reactive balance control against unpredictable support surface perturbations and to compare the effects of SES applied to the trunk and the lower legs.

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Article Synopsis
  • CCR4-NOT is a complex involved in various stages of gene regulation like transcription, mRNA decay, and protein ubiquitylation, with extensive research in yeast but limited knowledge in mammals.
  • A study using an auxin-induced degron system showed that depleting key components CNOT1 and CNOT4 in human cells led to significant changes in mRNA stability and synthesis; CNOT1 depletion increased mRNA levels while CNOT4 depletion accelerated mRNA decay.
  • The results indicated that CCR4-NOT maintains the expression of certain transcriptional repressors (KZNFs), which in turn suppress retrotransposable elements (rTEs), establishing the complex as a crucial regulator of gene expression in mammals.
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