Successful Treatment of SCD-Related Priapism With Crizanlizumab: A Case Series.

Priapism, an unwanted, painful, prolonged erection that is unrelated to sexual stimulation, is a common complication of sickle cell disease (SCD). Priapic events in SCD are stuttering, meaning they occur repeatedly with intervening periods of detumescence. Without health care intervention, repeated episodes can lead to erectile dysfunction.

Social responsibility in research and innovation practice and policy across global regions, institutional types, and fields: Interview data and qualitative content analysis outputs revealing the perspectives and experiences of professionals.

The European Commission-funded RRING (Responsible Research and Innovation Networked Globally) Horizon 2020 project aimed to deliver activities that promoted a global understanding of Socially Responsible Research and Innovation (RRI). A necessary first step in this process was to understand how researchers (working across Global North and Global South contexts) implicitly understand and operationalise ideas relating to social responsibility within their day-to-day work. Here, we describe an empirical dataset that was gathered as part of the RRING project to investigate this topic.

Contrast Enhancement of RGB Retinal Fundus Images for Improved Segmentation of Blood Vessels Using Convolutional Neural Networks.

Retinal fundus images are non-invasively acquired and faced with low contrast, noise, and uneven illumination. The low-contrast problem makes objects in the retinal fundus image indistinguishable and the segmentation of blood vessels very challenging. Retinal blood vessels are significant because of their diagnostic importance in ophthalmologic diseases.

Evaluating the use of a 22-pathogen TaqMan array card for rapid diagnosis of respiratory pathogens in intensive care.

Pneumonia is highly prevalent in intensive care units (ICUs), with high associated mortality. Empirical treatment prioritizes breadth of coverage while awaiting laboratory diagnosis, often at the expense of antimicrobial stewardship. Microarrays use multiple parallel polymerase chain reactions to enable a rapid syndromic approach to laboratory diagnosis.