Publications by authors named "O Spinelli"

The GIMEMA LAL2317 protocol investigated the frontline chemotherapy-blinatumomab combination in adult Philadelphia- CD19+ B-lineage acute lymphoblastic leukemia (Ph- B-ALL) to improve minimal residual disease (MRD) response and clinical outcome. Two cycles of intravenous blinatumomab were administered after chemotherapy cycles 3 and 6. The primary endpoint was the rate of molecular MRD negativity following blinatumomab 1.

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Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) is a haemato-inflammatory syndrome genetically defined by somatic mutations in the X-linked UBA1 gene, typically Val/Thr/Leu substitutions at the Met41 hotspot. Clinical manifestations are heterogeneous and refractory to most haemato-rheumatological treatments. To date, no guidelines exist for the management of VEXAS, and scarce is the evidence on methodology and clinical significance of longitudinal UBA1 clonal burden evaluation upon therapy.

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Article Synopsis
  • Acute lymphoblastic leukemia (γδ T-ALL) is a rare and complex condition in children, prompting a study of 200 pediatric cases to identify its clinical and genetic characteristics.
  • The research revealed that very young children (under 3 years) with γδ T-ALL face a significantly high risk and display specific genetic changes, particularly involving STAG2 inactivation and LMO2 activation.
  • Importantly, their findings suggest that targeting DNA repair pathways linked to STAG2 inactivation with specific drugs could offer new treatment options and help classify patients based on their risk levels.
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Article Synopsis
  • - Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative treatment for patients with Myelodysplastic syndromes (MDS), traditionally evaluated using the International Prognostic Scoring System-Revised (IPSS-R).
  • - Recent advancements in next generation sequencing have led to the development of molecular prognostic scores like IPSS-M, which provide more detailed risk assessment for MDS patients.
  • - A study analyzing 57 MDS patients showed that nearly half were re-stratified from IPSS-R to IPSS-M, indicating better prognostic value with IPSS-M, particularly highlighting that very high-risk patients had worse post-transplant outcomes, underscoring the importance of molecular data
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