Publications by authors named "O Spigset"
Dexamphetamine, lisdexamphetamine, and methylphenidate are central stimulant drugs widely used to treat Attention-deficit/hyperactivity disorder (ADHD), but poor adherence may lead to treatment failure and the drugs are also subject to misuse and diversion. Drug analysis in oral fluid may thus be useful for monitoring adherence and misuse. We measured drug concentrations in oral fluid and urine after controlled dosing to investigate detection windows and evaluate the chosen cut-offs.
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- Cetirizine is an antihistamine used for treating allergies and is often prescribed to breastfeeding mothers, although its effects on infants through breast milk are not well-documented.
- A population pharmacokinetic (popPK) model was created using data from a study of 35 breastfeeding women to predict cetirizine levels in breast milk and calculate the relative infant dose (RID).
- The study found a mean RID of 1.99%, indicating low exposure for infants, and suggests that cetirizine is generally safe for use during breastfeeding.
Background: Changes in gastrointestinal physiology following bariatric surgery may affect the pharmacokinetics of drugs. Data on the impact of bariatric surgery on drugs used for attention-deficit/hyperactivity disorder (ADHD) are limited.
Methods: In patients treated with ADHD medication and undergoing bariatric surgery, serial drug concentrations were measured for 24 h preoperatively and one, six and 12 months postoperatively.
Background: Bariatric surgeries may affect the pharmacokinetics of medications through alterations of the gastrointestinal physiology. Pharmacokinetic changes of first-line antiseizure medications such as lamotrigine and valproate following bariatric treatment have received little research attention so far.
Methods: In our prospective case study we included lamotrigine- or valproate-treated patients undergoing bariatric surgery at hospitals in Central Norway.