Publications by authors named "O Soritau"
Article Synopsis
- The study aims to create dual-modal organic-nanoagents for treating early-stage cutaneous melanoma, focusing on improving cancer therapy and real-time imaging techniques using nanotechnology and NIR molecular imaging.
- PLGA nanoparticles were developed to encapsulate a specific near-infrared dye, tested for their effectiveness, stability, and biocompatibility both in vitro and in vivo, showing promising results in enhancing photothermal therapy for melanoma treatment.
- Findings indicated that the nanoparticles could efficiently induce localized hyperthermia in tumor regions, promoting cellular death and immune response while minimizing damage to surrounding healthy tissue, suggesting a potential for more effective and safer melanoma therapies.
Background: Cancer stem-like cells (CSCs) have been extensively researched as the primary drivers of therapy resistance and tumor relapse in patients with breast cancer. However, due to lack of specific molecular markers, increased phenotypic plasticity and no clear clinicopathological features, the assessment of CSCs presence and functionality in solid tumors is challenging. While several potential markers, such as CD24/CD44, have been proposed, the extent to which they truly represent the stem cell potential of tumors or merely provide static snapshots is still a subject of controversy.
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- To combat tooth enamel demineralization caused by acid erosion and other factors, this study developed four toothpaste formulations featuring 4% calcined synthetic hydroxyapatite (HAP) and 1.3% birch extract.
- *The research utilized in vitro tests on artificially demineralized enamel slices to assess the effectiveness of these toothpaste formulations in repairing enamel and promoting remineralization.
- *Results showed significant restorative properties, with enamel normalization occurring in just 10 days, and optimal remineralization achieved after 30 days, indicating that these toothpastes enhance enamel health.*
Article Synopsis
- Birth-associated tissues and their factors, known as perinatal derivatives (PnD), show promise for treating various health conditions due to their biological properties, but their clinical use is hindered by inconsistent protocols in research.
- The paper introduces the PnD e-questionnaire, designed to evaluate existing methods for obtaining and analyzing PnD, aiming to promote standardized practices across studies.
- It also suggests essential reporting criteria for researchers to enhance transparency and reproducibility, ultimately supporting the transition of PnD research from the lab to clinical applications.
This research work aims to develop functional toothpastes with combined enamel remineralization and antibacterial effects using nano-hydroxyapatites (nHAPs) and birch extract. Eleven toothpastes (notated as P1-P11) were designed featuring different concentrations of birch extract and a constant concentration of pure nHAPs or substituted nHAPs (HAP-5%Zn, HAP-0.23%Mg-3.
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