Publications by authors named "O Shetty"
Background: The utility of Next-Generation-Sequencing (NGS) in patients of non-small-cell-lung-cancer (NSCLC) has led to an exponential increase in the identification of driver-gene alterations, however, Indian NGS data was lacking.
Materials And Methods: This retrospective study conducted between May'2019 and Dec'2023 included histologically confirmed NSCLC cases with NGS testing done on tissue and/or liquid biopsy samples prior to treatment initiation. We reported the frequency of driver-gene alterations, clinicopathological profile, treatment patterns, and outcomes [Overall-Survival (OS)].
Aim: The aim of this study was to investigate and compare the antimicrobial effects of an 810-nanometer diode laser, utilizing or not utilizing toluidine blue as a photosensitizer, in the management of peri-implant mucositis.
Settings And Design: The present study was carried out in 30 implant sites in 15 patients with peri-implant mucositis with a specific inclusion and exclusion criteria. 15 sites were treated utilizing a diode laser (control group) and 15 with photodynamic therapy (test group) in a split-mouth format.
Article Synopsis
- ALC-positive lung cancers generally respond well to oral tyrosine kinase inhibitors, with Lorlatinib being a preferred option after previous treatments; this study examines its use in patients who progressed or couldn't tolerate earlier therapies.
- In a study of 38 patients treated with Lorlatinib, most had extensive metastatic disease (mainly to the brain and bones), with a median follow-up of 49 months, revealing that 84% experienced disease control.
- Results indicated a median progression-free survival of 16 months and overall survival of 22 months, with common side effects including elevated cholesterol and triglycerides; some patients needed dose adjustments due to these toxicities.
Objective: Sporadic optic chiasmatic-hypothalamic gliomas (OCHGs), though histologically low-grade tumors, manifest as aggressive neoplasms radiologically, leading to difficulty in diagnosis. Molecular alterations of the BRAF gene are detectable in a majority of sporadic OCHGs. The purpose of our study was to elucidate the characteristic imaging features of sporadic OCHGs and to investigate whether imaging phenotypes could potentially correlate with specific BRAF gene alterations associated with these tumors.
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