Publications by authors named "O Shamriz"
Background: Risk factors for progression of adenovirus (AdV)-associated bronchiolitis (AdV-B) to post-infectious bronchiolitis obliterans (PIBO) are poorly defined. We aimed to investigate this in a multicenter cohort.
Methods: A multicenter hospital-based analysis included children admitted with AdV-B in Jerusalem during 2016-2022.
Article Synopsis
- Immune checkpoint inhibitors (ICI) for cancer like pembrolizumab and nivolumab can lead to immune-related adverse events (Eo-irAE), including high eosinophil levels that may predict positive treatment responses but can also cause significant organ dysfunction.
- This study evaluates the use of interleukin (IL) 5-axis inhibition to treat Eo-irAE, using medications like mepolizumab and benralizumab in three patients who developed these adverse effects after ICI therapy.
- Results showed rapid improvement in symptoms and a reduction in eosinophil levels with no negative impacts from the IL-5 targeted treatments, indicating they can be effective in managing Eo-irAE in cancer patients undergoing ICI
The caspase activation and recruitment domain 11 (CARD11) gene encodes a scaffold protein required for lymphocyte antigen receptor signaling. Dominant-negative, loss-of-function (LOF) pathogenic variants in CARD11 result in CARD11-associated atopy with dominant interference of NF-κB signaling (CADINS) disease. Patients with CADINS suffer with severe atopic manifestations including atopic dermatitis, food allergy, and chronic spontaneous urticaria in addition to recurrent infections and autoimmunity.
View Article and Find Full Text PDFBackground: Accumulating evidence suggests that food-induced anaphylaxis (FIA) may induce different psychological disorders (PDs). In this study, we aimed to further evaluate the effect of FIA, specifically when occurring in early life, on subsequent PDs development.
Methods: We conducted a population-based, retrospective, matched-cohort study of pediatric patients (age ≤ 18 years) treated at the "Clalit" healthcare organization during the period 2001-2021.