Publications by authors named "O Sepai"

The objective of this study is to report recent PCDD/F and PCB human milk concentrations in the United Kingdom (UK) and relate these to two proxies for exposure to municipal waste incinerator (MWI) emissions. As part of the Breast milk, Environment, Early-life, and Development (BEED) study, primiparous individuals were recruited from within 20 km of English MWIs between 2013 and 2015 and asked to provide human milk samples. The samples were analysed for quantitative concentrations of 17 PCDD/F and 12 PCB congeners.

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Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed determinants of AA exposure, measured by urinary mercapturic acids of AA (AAMA) and glycidamide (GAMA), its main metabolite, in 3157 children/adolescents and 1297 adults in the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data and quality assured measurements of AAMA and GAMA (urine collection: 2014-2021), the short-term validated biomarkers of AA exposure, were obtained from four studies (Italy, France, Germany, and Norway) in children/adolescents (age range: 3-18 years) and six studies (Portugal, Spain, France, Germany, Luxembourg, and Iceland) in adults (age range: 20-45 years).

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Article Synopsis
  • The research investigates the impact of organophosphate flame retardants on children's neurodevelopment, focusing on two European cohorts: the Odense Child Cohort from Denmark and the PCB cohort from Slovakia.
  • Neurodevelopment was assessed using children's IQ scores from the Wechsler Intelligence Scale, and urine samples were analyzed for organophosphate metabolites.
  • Results revealed a slight negative trend in neurodevelopment scores associated with bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) in the Danish cohort, while no significant associations were found with diphenyl phosphate (DPHP) or in the Slovakian cohort.
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