Synergy between a non-neuroleptic thioxanthene stereo-isomer and penicillin in vivo.

Some neuroleptic drugs of the phenothiazine and thioxanthene groups have an antimicrobial effect in vitro. This is also true for neuroleptically inactive stereo-isomeric analogs of the thioxanthenes e.g.

Peroperative penicillins, bacteremia, and pelvic inflammatory disease in association with induced first-trimester abortion.

In a clinical, controlled trial including 474 women, 250 were randomised to prophylactic treatment with penicillin/pivampicillin and 224 to placebo treatment. Cervical, uterine, and blood cultures were obtained at abortion. In the treatment group, 13 percent developed bacteremia versus 14 percent in the placebo group.

The pneumococcus and the mouse protection test: importance of the lag phase in vivo.

During development of a mouse protection test with a pneumococcus type 3 we noted the importance of the immediate post-challenge lag phase of the bacteria in vivo for the effective timing of treatment with different antibiotics. The lag phase, lasting 6-8 h after intraperitoneal challenge and parallel in peritoneum and blood, was reproducible with the same and three other strains of pneumococcus type 3. Penicillin administration during the lag phase had no effect upon survival of the mice, while a significantly improved effect was obtained after treating the mice with penicillin during the bacterial growth phase.

Pseudomonas cepacia in 16 non-fatal cases of postoperative bacteremia derived from intrinsic contamination of the anaesthetic fentanyl. Clinical and epidemiological observations in Denmark and Holland.

From Nov. 15 to Dec. 17, 1977, Pseudomonas cepacia was isolated from the blood of 16 patients in Odense, Denmark, and Nijmegen, Holland, 2--5 days after an operation with general anaesthesia.