Publications by authors named "O Sanmartin"
Paraneoplastic Dermatomyositis: A 25-Patient Series From a Cancer Center.
Actas Dermosifiliogr
November 2024
Article Synopsis
- Immunotherapy with avelumab has transformed treatment for metastatic Merkel cell carcinoma (MCC), showing a 57% overall response rate in a study of 14 patients.
- Among the patients, 29% experienced complete responses, while another 29% had partial responses, especially those with single metastatic sites (83% effective).
- However, the treatment was less effective in patients with bone metastases, and factors like PD1-L expression and MCPyV positivity didn’t show a clear link to treatment responses.
Introduction: Since the field of dermatopathology is not an exact science, it is subject to personal subjectivity, which sometimes causes disagreements on the diagnosis and assessment of some histological features. In the case of melanoma, some variables such as regression are associated with low interobserver agreement. On the contrary, other variables such as the measurement of Breslow thickness show high reproducibility.
View Article and Find Full Text PDFBackground And Objective: Cutaneous squamous cell carcinoma (cSCC) is the second leading cause of skin cancer mortality in Europe. Few studies have analyzed the different pathways of this tumor progression in its natural history. The main objective of this study was to analyze the different metastatic and progression pathways and their temporal occurrence in the evolution of cSCC.
View Article and Find Full Text PDFBackground: The survival benefit of sentinel lymph node biopsy (SLNB) in immunocompetent and immunosuppressed patients with high-risk cutaneous squamous cell carcinoma (cSCC) has not been established.
Objective: To determine whether SLNB improves disease-specific survival (DSS) in high-risk cSCC. Secondary objectives were to analyse disease-free survival, nodal recurrence-free survival and overall survival (OS).