Tolerance to cooked egg in infants with risk factors for egg allergy after early introduction of baked egg.

Egg allergy (EA),along with cow's milk allergy (CMA) and atopic dermatitis (AD is one of the most frequent allergies in children. Tolerance to food allergens seems to be related to the early and regular intake and the cooking method. The objective of this study is to prove that the introduction of baked eggs at 4-6 months of age and its daily maintenance for 6 months prevents EA.

Circulating CD34 Cells: A New Biomarker of Residual Pulmonary Vascular Obstruction after Pulmonary Embolism.

Pulmonary embolism (PE) is a life-threatening condition with long-term complications, including residual pulmonary vascular obstruction (RPVO). RPVO is associated with an increased risk of venous thromboembolism recurrence, chronic symptoms, and reduced quality of life. We hypothesize that an endothelial activation and vascular injury play a central role in the pathophysiology of RPVO.

Epigenome-wide association study of pregnancy exposure to green space and placental DNA methylation.

Green space exposure during pregnancy has been associated with lower risk of adverse birth outcomes, but the biological mechanisms remain unclear. Epigenetic changes, such as DNA methylation (DNAm), may contribute to this association. The placenta, crucial for foetal development, has been understudied in relation to prenatal green space exposure and DNAm on a genome-wide scale.

Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial.

Background: In patients with venous thromboembolism at high risk of recurrence for whom extended treatment with direct oral anticoagulants has been indicated, the optimal dose is unknown. We aimed to assess efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants in patients in whom extended anticoagulation has been indicated.

Methods: RENOVE was a non-inferiority, investigator-initiated, multicentre, randomised, open-label, blinded endpoint trial done in 47 hospitals in France.

Deficiencies causes in road construction scheduling: Perspectives from construction professionals.

Effective construction scheduling is crucial for the success of road projects. However, deficiencies in this scheduling can lead to significant challenges such as delays, cost overruns, and litigation. Therefore, project managers need to understand the causes that contribute to these deficiencies thoroughly.