[Molecular functions of polyamines in neoplastic growth and their role in control of the NF-kappaB transcription factor in experimental tumors cells].

PA were found to promote creation of the NF-kappaB complex with the correspondent DNA sequences (NRE), p50 NF-kappaB-subunit affinity with NRE is essentially magnified in PA presence. This is one of important demonstrations of PA involvement in transcription control. NF-kappaB activity in experimental mammary tumors cells was shown to depend on PA metabolism.

[Effect of plant biocomposites based on Georgian tea "per se" and in combination with cisplatin on Walker carcinosarcoma W-256 and Guerin's carcinoma growth rate in rats].

Green tea biocomposite had effectivey hampered the growth of rat Walker W-256 carcinoma and in less extent rat Guerin's carcinoma. Black tea biocomposite had not practically influenced on Guerin's carcinoma growth. The biocomposite from green tea and extract from red vine rind and lemon suppressed at the level of tendency the growth of rat Walker W-256 carcinoma.

[Effect of soy products on graft tumor growth in rats].

Moderate consumption of a curd-like product made of thermally-treated soy (SPT) led to the retardation of hormone-dependent (Walker W 256 carcinosarcoma in females) and some less hormone-independent (Guerin's carcinoma in males) tumor growth in rats. Excessive (ad libitum) consumption of the same product led to accelaration of W 256 tumor growth. A similar product made of raw soy (SPR) accelerated the growth of W-256 carcinosarcoma and made not any effect on the growth of Guerin's carcinoma.

The Effect of Smooth Muscle Cells and Leukocytes on HSV-1 Reproduction in Cultured Human Endothelial Cells.

The ability of intima smooth muscle cells (SMCs) and blood leukocytes to control the development of Herpes simplex type 1 virus (HSV-1) infection in human vascular endothelial cells (ECs) was studied under a co-culture conditions. It was shown that cultured ECs supported HSV-1 reproduction followed by cytopathogenic effect (CPE) and accumulation of infectious virus in the cell culture medium. At the multiplicity of infection (MOI) ranging from 1 to 0.