Publications by authors named "O Said"
Background: Breast cancer remains the most common invasive cancer in women worldwide. Triple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options. Trastuzumab (Tz) is typically used to treat HER2-positive breast cancers, but its potential in TNBC is unclear.
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- Mitochondria are vital for energy production and play important roles in cellular processes and stress responses, particularly in plants facing environmental challenges like drought.
- This study investigates RNA editing patterns in distinct wheat cultivars under drought conditions to better understand how plants adapt to stress.
- Results indicate significant RNA editing, especially C-to-T conversions, affecting protein structure and regulatory functions, with differences in responses between drought-tolerant and sensitive wheat varieties.
Background: Despite the availability of evidence-based treatments for anorexia nervosa (AN), remission rates are moderate, and mortality is high. Olanzapine is used as adjunct therapy for AN in case of insufficient response to first-line treatments, even though the evidence is limited. Its effect on eating disorder (ED) psychopathology, its efficacy and tolerability, and its acceptability and adherence rate are unclear.
View Article and Find Full Text PDFBackground: The association between keratoconus and thyroid gland dysfunction (TGD) remains controversial. We aimed to determine the frequency of keratoconus among patients with laboratory-confirmed, treatment-naive TGD compared with that of age- and sex-matched healthy controls. Moreover, we investigated the potential relationship between TGD and corneal topographic and tomographic parameters.
View Article and Find Full Text PDFBackground: The OPEN feasibility trial testing olanzapine in anorexia nervosa (AN) in young people (YP) was not successful due to poor recruitment. This study aims to understand clinicians' views and experiences of using olanzapine in AN and the challenges in implementing the trial in National Health Service (NHS) clinical settings.
Methods: We conducted qualitative interviews with eating disorders (ED) clinicians involved with the study (n = 11).