Publications by authors named "O Sai Satish"
Congestive heart failure (CHF) is the leading cause of morbidity and mortality in the elderly worldwide. Although many biomarkers associated with in heart failure, these are generally prognostic and identify patients with moderate and severe disease. Unfortunately, the role of biomarkers in decision making for early and advanced heart failure remains largely unexplored.
View Article and Find Full Text PDFArticle Synopsis
- Oxidative stress occurs when there’s an imbalance between oxidants and antioxidants, leading to the release of reactive oxygen species (ROS) that can damage vascular functions, with Cyclophilin A (CypA) enhancing these damaging effects in cardiovascular diseases.
- A study of 103 adults, 73 with coronary artery disease (CAD), measured serum levels of CypA and other biomarkers, revealing significantly higher levels in CAD patients compared to controls, and established correlations between CypA and inflammation markers.
- Results indicated that CypA and hsCRP levels can be used as potential indicators for CAD severity, showing high sensitivity and specificity at certain cut-off values, suggesting their relevance in diagnosing and understanding the
This study aimed to evaluate the effect of thiamine supplementation on left ventricular (LV) systolic function in patients of alcoholic cardiomyopathy(ACM) presenting with acute heart failure(HF). 11 newly diagnosed patients were included. They were treated with 3 days of intravenous(IV) therapy with thiamine followed by oral supplementation.
View Article and Find Full Text PDFArticle Synopsis
- Heart failure (HFpEF) is difficult to diagnose, and NT-proBNP has limited effectiveness for this condition, prompting research into serum Galectin-3 as a potential biomarker.
- A study involving 63 heart failure patients showed that both Galectin-3 and NT-proBNP levels were significantly higher than those in controls, with Galectin-3 demonstrating better sensitivity and area under the curve (AUC) for diagnosis.
- Results indicate that Galectin-3 could serve as a more reliable biomarker for HFpEF, and using both Galectin-3 and NT-proBNP together may enhance diagnostic accuracy.
Background And Objectives: Infective endocarditis (IE) is a microbial infection of the endothelial surface of the cardiac-valves. Rapid diagnosis, effective treatment and prompt recognition of complications are essential, in order to improve the outcome. We retrospectively reviewed and determined the clinical characteristics, microbiological profile and management strategies of IE cases, changing microbial spectrum of pathogens and outcome in Native Valve Endocarditis (NVE) and Prosthetic Valve Endocarditis (PVE) cases.
View Article and Find Full Text PDF