Publications by authors named "O S Yakovenko"

Graphite nanoplatelets (GNPs)-the segregated ultra-high molecular weight polyethylene (UHMWPE)-based composites with hybrid filler-decorated with FeO were developed. Using X-ray diffraction and scanning electron microscopy, it was shown that the decorated component has the shape of separate granules, or their clusters were distributed evenly over the GNPs surface. The individual FeO nanoparticles are predominantly rounded, with diameters of approximately 20-60 nm.

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Platelets are routinely stored at room temperature for 5-7 days before transfusion. Stored platelet quality is traditionally assessed by Kunicki's morphology score. This method requires extensive training, experience, and is highly subjective.

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The FimH protein of Escherichia coli is a model two-domain adhesin that is able to mediate an allosteric catch bond mechanism of bacterial cell attachment, where the mannose-binding lectin domain switches from an 'inactive' conformation with fast binding to mannose to an 'active' conformation with slow detachment from mannose. Because mechanical tensile force favors separation of the domains and, thus, FimH activation, it has been thought that the catch bonds can only be manifested in a fluidic shear-dependent mode of adhesion. Here, we used recombinant FimH variants with a weakened inter-domain interaction and show that a fast and sustained allosteric activation of FimH can also occur under static, non-shear conditions.

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