Publications by authors named "O S Stupchenko"

Early in the new millennium, sepsis remains one of the most urgent problems of modern reanimatology. Endotoxin, a component of the cell wall of gram-negative bacteria is of paramount importance in the pathogenesis of sepsis. Complex intensive care for severe sepsis involves selective endotoxin hemoperfusion with Polymyxin B and Alteco LPS adsorber, which has been performed in 2 patients.

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End-stage of chronic renal failure (CRF) is frequently associated with cardiac and vascular comorbidities requiring cardiosurgical interventions. Over 9 years, from 2000 to 2009, the A. N.

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Aims: The purpose of this publication is to evaluate the first experiences with the supplemental use of selective endotoxin adsorption cartridges in the treatment of critically ill patients complicated by severe sepsis after cardiac surgery.

Methods: Thirteen patients with Gram-negative sepsis underwent the procedure of selective lipopolysaccharide (LPS) adsorption using Alteco adsorber (group I) or Toraymyxin columns (polymyxin-B-immobilized fiber) (group II).

Results: This therapy positively influenced the course of sepsis.

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Early in the new millennium, sepsis remains one of the most urgent problems of modern medicine as before in view of a steady tendency for a rise of morbidity rates and for stably high mortality rates in patients (from 30 to 70%). The endotoxin lipopolysaccharide (LPS) of the cell wall of gram-negative bacteria plays the most important role in the pathogenesis of sepsis. This paper assesses the first experience in using endotoxin-selective sorption technologies within complex intensive care of critically ill patients with infectious and septic complications after cardiac surgery.

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