Effects of various modes of sonication with low frequency ultrasound on in vitro survival of human tumor cells.

The effect of low frequency ultrasound in the cavitation (5-15 sec exposure) and subcavitation (5-210 sec exposure) modes on in vitro survival of cultured human tumor cells was studied. Analysis of the dose-effect curves and mathematical estimation of the effects low-frequency ultrasonication in the subcavitation mode on cell membranes helped to choose time intervals of tumor cell sonication ensuring potentiation of the cytostatic effects.

[Effect of lipophilic derivatives of a divinyl ether-maleic anhydride copolymer on immunocompetent cells].

A series of lipophilic derivatives of the copolymer divinyl ether with maleic anhydride were synthesized and tested for their effects on immunocompetent cells. Increases in the length of a hydrophobic moiety and its quantity in the polymer chain of the agent were demonstrated to substantially modify the factors of animals' humoral and cell-mediated immunity. This phenomena is well associated with the examined superficial qualities of solutions of the agents and their mycelium forming capacity.