Publications by authors named "O S Olajide"
Article Synopsis
- Reductions in estrogen can lead to cognitive decline by impairing mitochondrial function in the hippocampus, particularly affecting the entorhinal cortex.
- Female rats underwent various procedures to assess the impact of estrogen deficiency, with findings showing that mitochondrial respiration decreased four weeks after ovariectomy but was maintained with estrogen supplementation.
- The study revealed that the absence of estrogen leads to oxidative stress and reduced expression of important mitochondrial and synaptic proteins, suggesting a connection between low estrogen levels and declining cognitive functions.
Infertility has become a significant health burden around the globe as it is believed that 15 % of married couples struggle with infertility, with half of the problem accrued to the male. The issue of male infertility could be traced to insufficient or absence of spermatozoa. Glucose metabolism is essential for continued spermatogenesis and for the reproductive potential of sperm cells.
View Article and Find Full Text PDFThe existing literature on neurodegenerative diseases (NDDs) reveals a common pathological feature: the accumulation of misfolded proteins. However, the heterogeneity in disease onset mechanisms and the specific brain regions affected complicates the understanding of the diverse clinical manifestations of individual NDDs. Dementia, a hallmark symptom across various NDDs, serves as a multifaceted denominator, contributing to the clinical manifestations of these disorders.
View Article and Find Full Text PDFBackground: AC-186 (4-[4-4-Difluoro-1-(2-fluorophenyl) cyclohexyl] phenol) is a neuroprotective non-steroidal selective oestrogen receptor modulator. This study investigated whether inhibition of neuroinflammation contributed to neuroprotective activity of this compound.
Methods: BV-2 microglia were treated with AC-186 (0.
Synergistic effect of drying methods and ultrasonication on natural deep eutectic solvent extraction of phytochemicals from African spinach (Amaranthus hybridus) stem.
J Food Sci
November 2024
The study evaluated the combined effects of drying methods (air drying [AD], hot AD [HAD], microwave drying [MD], and freeze-drying [FD]) and ultrasonication parameters (sonication temperature [STemp]: 40, 50, and 60°C) and heating time (STime: 60 and 120 min) on natural deep eutectic solvent (NADES) extraction of phytochemicals from Amaranthus hybridus stem. Increasing the STemp increased the extraction yield (ECY) of the phytochemicals for all drying methods but increase in the heating time reduced the ECY slightly. MD combined with 60°C ST showed the highest ECY (53%), whereas HAD combined with 40°C ST had the lowest ECY (18%).
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