Publications by authors named "O S Kucuk"
Introduction: Advanced penile squamous cell carcinoma (pSCC) is a rare and aggressive malignancy with a poor prognosis and an unmet need for biomarkers. We performed a retrospective evaluation of real-world efficacy, safety outcomes, and baseline inflammatory biomarkers in patients with advanced pSCC treated with immune checkpoint inhibitors (ICIs).
Methods: We performed a retrospective review of patients with advanced pSCC who received ICIs from 2012 to 2023 at the Winship Cancer Institute of Emory University in Atlanta, GA.
The Role of Curcumin in Preventing Naturally Occurring Leiomyoma in the Galline Model.
Pharmaceuticals (Basel)
December 2024
Background: Leiomyoma (LM) is the most commonly identified tumor in the genital tract, occurring in 70-80% of women. The only treatment option is surgery, which significantly influences healthcare costs and negatively influences women's survival and reproductive capacity. Therefore, identifying safe and effective chemopreventive and treatment modalities is needed.
View Article and Find Full Text PDFThis study aimed to investigate the protective effects of vitamin B complex and alpha-lipoic acid (ALA) pre-treatments on hepatic ischemia-reperfusion injury (IRI) in rats, focusing on their potential to enhance antioxidant defense mechanisms and reduce post-ischemic liver damage. Thirty male Wistar albino rats were divided into four groups: sham group (n = 10), IRI group (n = 10), vitamin B group (n = 10), vitamin B + ALA group (n = 10). In the IRI, vitamin B, and vitamin B + ALA groups, the rats underwent 45 min of hepatic ischemia followed by 60 min of reperfusion.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates oxidative stress levels in ICU patients by measuring total oxidant level (TOS), total antioxidant level (TAS), and oxidative stress index (OSI) before treatment starts.
- In total, 153 patients were analyzed, along with 60 healthy controls, revealing significantly higher TOS and OSI in patients, indicating elevated oxidative stress.
- The findings show that patients also had increased levels of inflammation markers like ferritin, C-reactive protein (CRP), and procalcitonin (PCT), suggesting a strong correlation between oxidative stress and inflammation in critically ill individuals.