[Experience of contemporary treatment of radiation burns in individuals subjected to ionizing radiation].

The article presents new approach to treatment of radiation disorders presenting as indolent ulcers. The approach is based on autologous multipotent mesenchimal stromal cells applied locally and injected around the injuried zone. The ulcers heal due to the fact that the transplanted cells stimulate local regeneration processes, angiogenesis, ceased inflammation and apoptosis.

[Mesenchymal stem cells transplantation in the treatment of radiation skin lesions].

Transplantation of mesenchymal stem cells, both at early and later stage after local exposure of rats source beta radiation dose, 90Sr/90Y 140 GR, stimulates recovery of damaged skin. Diminution area local radiation injuries and accelerate healing radiation ulcers. Clinically shows the high efficiency of the transplantations autologous mesenchymal stem cells in treatment of deep beam ulcers, intractable standard conservative treatment.

[Characteristics of human lipoaspirate-isolated mesenchymal stromal cells cultivated under a lower oxygen tension].

In the present study we investigated the effect of low oxygen concentration in the cultivation medium on proliferation, viability and immunophenotype of human mesenchymal stromal cells isolated from lipoaspirate (lMSC). It was shown that proliferation activity of the cells under hypoxic conditions was, on average, 2.9 times higher compared to that under commonly accepted normoxic conditions.

[Effects of hyperoxic gas mixtures on the proliferative and migrative activities of cultivated endothelial cells of humans].

Proliferation and migration of endothelial cells of humans were studied in hyperoxic gas mixtures varying in percentage of oxygen and argon. Exposure to one or the other hyperoxic mixture was repeated, short (3 hrs) or long (18 hrs). The most significant inhibition of proliferation was observed after three long exposures in 100% O2 and the least signficant inhibition was caused by the gas mixture containing 89% of O2, 4.