[Capabilities of hypoglycemic therapy in women with decompensated type 2 diabetes mellitus].

Aim: to comparatively evaluated the efficiency of various sugar-lowering therapy (SLT) options in patients with decompensated type 2 diabetes mellitus (T2DM).

Subjects And Methods: One hundred and eighty-two women who were over 55 years of age with a more than 3-5-year history of T2DM and more than one-year decompensation, abdominal obesity (AO), arterial hypertension, and concomitant treatment-matched were randomized into 4 groups: (1) metformin (n=46); (2) a combination of metformin and gliclaside MB (n=47); (3) metformin and insulin (n=44); and (4) insulin (n=45). A follow-up was 12 months.

[Dynamics of structural-functional parameters of cardiovascular system during use of complex therapy of women with type 2 diabetes mellitus].

Aim of the work was to study dynamics of parameters of cardiovascular system in women during use of various sugar lowering drugs in complex multifactorial therapy of type 2 diabetes mellitus (DM). We included in this 12 months study 182 women older than 55 years with type 2 DM, abdominal obesity and artrerial hypertension (AH). All women received angiotensin converting enzyme inhibitors and statins.

[Cardiovascular disorders and possibilities of their therapy in patients with type 2 diabetes mellitus and diabetic nephropathy].

The aim of the study was to assess specific cardiovascular lesions in patients with type 2 diabetes mellitus and diabetic nephropathy (DN) and search for the methods of their correction. It included 182 overweight or obese (abdominal type) women above 55 yr with arterial hypertension (AH) divided into groups with normal or low (less than 30 ml/day) albuminuria (n = 87), albuminuria (30-300 mg/day, n = 59), proteinuria (above 30 mg/day, n = 21), and stage I-IIa chronic renal insufficiency (CRI, n = 15). It was shown that structural geometric changes in the left ventricle (LV) with the prevalence of myocardial concentric hypertrophy and diastolic dysfunction (DD), enhanced myocardial hardness, and preserved systolic function undergo progression with increasing severity of DN and decreasing glomerular filtration rate combined with poorly controlled DM2, abnormal lipid profile, long history of AH in the absence of adequate AP control, signs of vascular atherosclerosis (thickening of intima and media in carotid arteries), and large number of macrovascular complications.

[Prevalence of arterial hypertension in women with type 2 diabetes mellitus and diabetic foot syndrome].

The aim of the study was to evaluate prevalence of arterial hypertension (AH), efficiency of preceding therapy, and quality of life (QL) in 50 women with type 2 diabetes mellitus (DM) and diabetic foot syndrome (DFS) and 139 DM patients without DFS. The analysis included individual outpatient medical records, results of AH verification (WHO, RSC, 2004), parameters of carbohydrate and lipid metabolism, insulin resistance (IR) index, and QL data (SF-36 questionnaire). The patients were above 55 years of age.

[Potential of combined hypoglycemic, antihypertensive, and hypolipidemic therapy in patients with diabetes mellitus and diabetic foot syndrome].

The objective of this study was to assess the potential of combined therapy in patients with types 1 and 2 diabetes mellitus (DM) and diabetic foot syndrome (DFS). A total of 157 patients with DFS were observed over 3 months including 25 with type 1 DM and 132 with type 2 DM. In addition, 563 subjects without DFS were included in the study.