Publications by authors named "O S Ekenze"
Article Synopsis
- Mild cerebral small vessel disease (CSVD) markers are common but only high CSVD burden increases stroke and dementia risk, potentially identified using a multi-marker CSVD score.
- In a study of 1,154 participants aged 55 and older, those with three or more CSVD markers had a significantly higher stroke risk during an 8.6-year follow-up.
- The findings suggest that assessing CSVD burden could enhance stroke risk identification, complementing traditional risk assessments like the Framingham Stroke Risk Profile.
Background: Hypertension is the most potent stroke risk factor and is also related to cerebral small vessel disease. We studied the relation between mid-to-late-life hypertension trends and cerebral white matter injury in community-dwelling individuals from the FHS (Framingham Heart Study).
Methods: FHS Offspring cohort participants with available mid-life and late-life blood pressure measurements and brain magnetic resonance imaging were included.
Perivascular spaces (PVS) visible on brain MRI signal cerebral small vessel disease (CSVD). The coexistence of PVS with other CSVD manifestations likely increases the risk of adverse neurological outcomes. We related PVS to other CSVD manifestations and brain volumes that are markers of vascular brain injury and neurodegeneration.
View Article and Find Full Text PDFBackground: Neurofilament light chain (NfL) is a marker of neuronal injury. Perivascular spaces (PVS) visible on magnetic resonance imaging (MRI) represent cerebral small vessel disease (CSVD) but their role as markers of neuronal injury needs further clarification.
Objective: To relate PVS burden according to brain topography and plasma NfL.
We studied the association between inflammatory biomarkers and magnetic resonance imaging (MRI) visible perivascular spaces (PVS) in Framingham Heart Study participants free of stroke and dementia. PVS in the basal ganglia (BG) and centrum semiovale (CSO) were rated with validated methods and categorized based on counts. A mixed score of high PVS burden in neither, one or both regions was also evaluated.
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