[Neonatal injections of pharmacological agents and their remote genotype-dependent effects in mice and rats].

Experimental data were reviewed which demonstrated that the neonatal injection effects of certain biologically active drugs (ACTH(4-10) fragment and its analogue Semax, piracetam, caffeine, levetiracetam, busperone, etc.) could be detected in adult animals as changes in physiological and behavioral reactions and in several morphological traits as well. Audiogenic seizures proneness, anxiety-fear and exploration behavior as well as pain sensitivity were analyzed.

[The 1xC3 panel of recombinant inbred mouse strains. Presence or absence of pathologic neurologic traits of one of parental strains].

Mice from the earlier developed recombinant inbred strains (RIS), which were derived by crossing 101/HY mice (carrying the mut-1 allele determining increased susceptibility to the mutagenic action of alkylating compounds) with C3H/Sn mice (lacking this trait), were tested for the presence of two neurological pathologies, audiogenic epilepsy and splitting of pyramidal cell layer of the CA3 hippocampal field (specific only to 101/HY mice). It was demonstrated that segregation of RIS relative to these traits was independent from the presence or absence of the mut-1 allele. These findings suggested the appearance of mut-1-independent mutations in the 101/HY mice, which resulted in the development of neurological pathologies.

[Fine structure and culture characteristics of Lactobacillus plantarum].

The preparations of Lactobacillus plantarum 8-PA-3 cultures growing for 6, 8 and 10 hours were taken at the phase of exponential growth in a liquid malt-containing nutrient medium, and their ultrathin sections and replicas were studied after freeze-fracturing and etching by means of electron microscopy. The authors discuss the dynamics of development of structural-functional complexes in the cells, in particular, their membranous structures. Their morphogenesis is correlated with the functional requirements of the cells due to peculiarities of the population growth.