Publications by authors named "O S Amuda"
Dengue is a major global health threat, and there are no approved antiviral agents. Prior research using Cas13 only demonstrated dengue mitigation in vitro. Here we demonstrate that systemic delivery of mRNA-encoded Cas13a and guide RNAs formulated in lipid nanoparticles can be used to treat dengue virus (DENV) 2 and 3 in mice.
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- * The research utilized data from the National Health and Nutritional Health Surveys (NHANES) and identified sociodemographic factors (like race, age, education, poverty, and BMI) linked to PeMetSyn.
- * Findings show that the prevalence of PeMetSyn grew by over 150% for men and 130% for women, highlighting the need for early detection and intervention to prevent the progression to metabolic syndrome and related diseases.
Article Synopsis
- The study explored how Cannabis sativa (CS) and melatonin (M) affect the lipid profile and antioxidant systems in the brains of female Wistar rats.
- After 14 days of treatment, CS was found to increase certain antioxidant enzyme activities (like G6PD, GPx, and SOD) while decreasing nitric oxide levels, but did not change lipid profile parameters.
- Melatonin further enhanced the increase in G6PD levels, indicating its potential role in antioxidant modulation in the brain.
In an outbreak, effective detection of the aetiological agent(s) involved using molecular techniques is key to efficient diagnosis, early prevention and management of the spread. However, sequencing is necessary for mutation monitoring and tracking of clusters of transmission, development of diagnostics and for vaccines and drug development. Many sequencing methods are fast evolving to reduce test turn-around-time and to increase through-put compared to Sanger sequencing method; however, Sanger sequencing remains the gold standard for clinical research sequencing with its 99.
View Article and Find Full Text PDFSeroprevalence and Co-Infection of Human Immunodeficiency Virus (HIV) and Herpes Simplex Virus (HSV) Among Pregnant Women in Lokoja, North-Central Nigeria.
Iran Red Crescent Med J
October 2016
Background: Herpes simplex virus 1 (HSV-1) is normally associated with orofacial (orolabial) infections and encephalitis, whereas HSV-2 usually causes genital infections and can be transmitted from infected mothers to neonates. The evidence suggesting that HSV is facilitating the spread of the global human immunodeficiency virus (HIV) epidemic and the risk posed by these synergies to neonates in developing countries informed this study.
Objectives: To determine the seroprevalence and co-infection of HIV and HSV, as well as their associated risk factors, in Lokoja, Nigeria.