Publications by authors named "O Rousseau"
The main limitation to long-term lung transplant (LT) survival is chronic lung allograft dysfunction (CLAD), which leads to irreversible lung damage and significant mortality. Individual factors can impact CLAD, but no large genetic investigation has been conducted to date. We established the multicentric Genetic COhort in Lung Transplantation (GenCOLT) biobank from a rich and homogeneous sub-part of COLT cohort.
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- Toe-web (TW) intertrigo is a painful skin condition primarily caused by Gram-negative bacteria, often accompanied by eczema, which can lead to significant functional disability.
- A study was conducted to assess the effectiveness of a standardized treatment plan using topical corticosteroids over a 6-month follow-up for patients with GNB-TW intertrigo.
- Results showed no significant difference in disease duration between patients treated with the standardized plan and those treated without it, but relapses were less frequent in the standardized cohort.
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- The KTD-Innov study aims to address the lack of reliable biomarkers for kidney allograft rejection by analyzing a diverse group of kidney transplant recipients over one year, involving 733 participants across seven French centers.
- The study involved comprehensive data collection, including clinical, biological, immunological, and histological parameters, and developed a biobank with over 16,000 samples to facilitate future research.
- The findings reveal that the cumulative incidence of allograft rejection was 9.7% at one year, and the study population reflects the broader demographic of kidney transplant recipients in France and beyond, supporting its clinical relevance.
While nearly all computational methods operate on pseudonymized personal data, re-identification remains a risk. With personal health data, this re-identification risk may be considered a double-crossing of patients' trust. Herein, we present a new method to generate synthetic data of individual granularity while holding on to patients' privacy.
View Article and Find Full Text PDFKiT-GENIE is a monocentric DNA biobank set up to consolidate the very rich and homogeneous DIVAT French cohort of kidney donors and recipients (D/R) in order to explore the molecular factors involved in kidney transplantation outcomes. We collected DNA samples for kidney transplantations performed in Nantes, and we leveraged GWAS genotyping data for securing high-quality genetic data with deep SNP and HLA annotations through imputations and for inferring D/R genetic ancestry. Overall, the biobank included 4217 individuals (n = 1945 D + 2,272 R, including 1969 D/R pairs), 7.
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