High correlation between salivary MHPG and CSF MHPG.

Rationale: Determination of 3-methoxy-4-hydroxy-phenylglycol (MHPG) as a major metabolite of noradrenaline may reflect changes in noradrenergic activity dependent on psychiatric illness and drug therapy.

Objective: This study was designed to investigate the relationship between CSF and salivary MHPG, and thus the utility of saliva MHPG as a marker for CSF MHPG.

Method: Twenty-one paired samples of saliva and CSF were assayed for MHPG by solid-phase extraction and HPLC-ED.

Behavioral and neurochemical effects of anpirtoline and citalopram in isolated and group housed mice.

Acute effects of serotonergic drugs acting via different mechanisms were investigated by a social interaction test and subsequent determination of serotonin and dopamine metabolisms in mice housed in groups or isolated for 6 weeks. A resident/intruder test was performed with anpirtoline (5-HT1B receptor agonist in rodents; 1 mg/kg), citalopram (SSRI; 0.5 mg/kg) and saline treatment before animals were decapitated and different brain regions were frozen for subsequent HPLC-analyses.

Open field locomotion and neurotransmission in mice evaluated by principal component factor analysis-effects of housing condition, individual activity disposition and psychotropic drugs.

Effects of housing condition and individual disposition on dopaminergically and GABAergically influenced open field locomotion and neurochemistry were studied in mice. Mice characterized as high active (HAM) and low active (LAM) by a running-wheel test were housed in groups or isolated for 1 day, 1 week, 3, 6, 12 or 18 weeks before an open field test was performed with saline, apomorphine (0.75 mg/kg) or diazepam (1.

Dopaminergic parameters during social isolation in low- and high-active mice.

Alterations induced by social isolation (1 day to 18 weeks) in low- and high-active mice (LAM and HAM) were studied in respect to locomotor activity, [3H]-spiperone binding in the striatum, striatal, and cortical dopamine metabolism, and presynaptic dopaminergic sensitivity to apomorphine (0.75 mg/kg; i.p.