Publications by authors named "O Richel"
Article Synopsis
- The COVID-19 pandemic influenced population-level immune responses through infections, lockdowns, and vaccination efforts, potentially impacting various immune-mediated diseases.
- In a study of 1,895 asymptomatic individuals living with HIV, researchers assessed how these factors modified inflammatory profiles and immune responses between October 2019 and October 2021.
- Results showed that while mild COVID-19 infections had minimal long-term immune effects, lockdowns significantly increased immune responsiveness, and vaccinations moderately reduced it, suggesting lockdowns may have unexpected immunological consequences that warrant further investigation.
Occurrence and predictors of laboratory abnormalities during outpatient parenteral antimicrobial therapy - A multicenter cohort study to inform laboratory test monitoring.
J Infect
November 2024
Objectives: Evidence on the optimal frequency of laboratory testing during outpatient parenteral antimicrobial therapy (OPAT) is lacking. Therefore, we investigated how often and when laboratory abnormalities occur during OPAT and which factors are associated with these abnormalities.
Methods: We performed a multicenter cohort study in four Dutch hospitals among adult patients receiving OPAT and collected routinely obtained laboratory test results.
Dolutegravir/Lamivudine Is Noninferior to Continuing Dolutegravir- and Non-Dolutegravir-Based Triple-Drug Antiretroviral Therapy in Virologically Suppressed People With Human Immunodeficiency Virus: DUALING Prospective Nationwide Matched Cohort Study.
Open Forum Infect Dis
April 2024
Background: Confirming the efficacy of dolutegravir/lamivudine in clinical practice solidifies recommendations on its use.
Methods: Prospective cohort study (DUALING) in 24 human immunodeficiency virus (HIV) treatment centers in the Netherlands. HIV RNA-suppressed cases were on triple-drug antiretroviral regimens without prior virological failure or resistance and started dolutegravir/lamivudine.
Purpose: Obesity is rising among people with HIV (PLWH), sparking interest in bariatric surgery (BS) for this group. Yet, large-scale comparative research on BS outcomes in PLWH is lacking.
Methods: We performed a retrospective, matched cohort analysis in PLWH and HIV uninfected controls.
Purpose: Anal cancer is increasing in HIV+ men who have sex with men (MSM). Treatment options for its precursor, high-grade anal intraepithelial neoplasia (HGAIN), are suboptimal. In this phase I to II dose-finding study, we assessed the safety and efficacy of the human papillomavirus type 16 (HPV16) synthetic long peptide vaccine (SLP-HPV-01) in HIV+ MSM with HPV16-positive HGAIN.
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