Publications by authors named "O Reul"
Article Synopsis
- Postmenopausal osteoporosis, driven by estrogen deficiency, significantly increases fracture risk, making early fracture prediction crucial yet difficult.
- A study on ovariectomized rats aimed to investigate changes in inflammation, oxidative stress, and bone properties post-surgery, testing new imaging techniques for early detection of bone alterations.
- Results indicated that while OVX rats showed increased inflammation and oxidative stress, changes in bone hydration measured by ultrashort echo time MRI were noticeable as early as 2 weeks after surgery, although these did not correlate with bone turnover rates in the assessed time frame.
As international incidence of diabetes and diabetes-driven comorbidities such as chronic kidney disease (CKD) continue to climb, interventions are needed that address the high-risk skeletal fragility of what is a complex disease state. Romosozumab (Romo) is an FDA-approved sclerostin inhibitor that has been shown to increase bone mineral density and decrease fracture rates in osteoporotic patients with mild to severe CKD, but its effect on diabetes-weakened bone is unknown. We aimed to test Romo's performance in a model of combined diabetes and CKD.
View Article and Find Full Text PDFArticle Synopsis
- Type 2 diabetes (T2D) is linked to higher rates of fractures and related mortality, with effective mouse models for studying its impact on bone health being limited.
- The KK/A mouse model, with a mutation in the agouti gene, reliably induces T2D with persistent hyperglycemia in both male and female subjects, making it suitable for bone studies.
- Findings indicate that KK/A mice represent the early stages of T2D characterized by high blood glucose and insulin levels, though the presence of diabetic male control mice presents some limitations for comparison.
Article Synopsis
- Patients with chronic kidney disease (CKD) have a significantly higher risk of fractures due to changes in bone structure, specifically increased cortical porosity and diminished matrix hydration.
- The study involved inducing CKD in mice and testing the effects of mechanical loading and a drug, raloxifene, on bone properties over ten weeks.
- Results showed that combining mechanical loading with raloxifene treatment improved bone characteristics in CKD mice, leading to lower porosity and enhanced hydration, which could help reduce fracture risk.
Primary cilia have been involved in the development and mechanosensation of various tissue types, including bone. In this study, we explored the mechanosensory role of primary cilia in bone growth and adaptation by examining two cilia specific genes, IFT88 and MKS5, required for proper cilia assembly and function. To analyze the role of primary cilia in osteoblasts, Osx1-GFP:Cre mice were bred with IFT88 to generate mice with a conditional knockout of primary cilia in osteoblasts.
View Article and Find Full Text PDF