Publications by authors named "O Randerath"
Effect of a single pill concept on clinical and pharmacoeconomic outcomes in cardiovascular diseases.
Eur Heart J Cardiovasc Pharmacother
January 2025
Aims: Our study aimed to assess whether a single pill concept (SPC) is superior to a multi-pill concept (MPC) in reducing cardiovascular (CV) events, all-cause death, and costs in CV patients.
Method And Results: Anonymized medical claims data covering 2012-2018, including patients with hypertension, dyslipidaemia, and CV diseases who started a drug therapy either as SPC or identical MPC were analysed after 1:1-propensity score matching. Hospitalizations with predefined CV events, all-cause mortality, and costs were studied in 25 311 patients with SPC and 25 311 patients with MPC using incidence rate ratios (IRRs) and non-parametric tests for continuous variables.
Article Synopsis
- Single-pill combinations for treating hypertension improve patient adherence to medication compared to taking multiple pills, which may lead to better health outcomes.
- A study using data from over 57,000 hypertensive patients analyzed the effects of single pills versus multiple pills on medication persistence and health outcomes such as cardiovascular events and all-cause mortality.
- The findings indicate that single-pill therapy significantly lowers all-cause mortality and cardiovascular events while enhancing medication persistence, supporting current health guidelines for hypertension treatment.
Purpose: Discrepancies exist between guideline recommendations and real-world practice of blood pressure (BP) measurements. The aim of this study was to assess, with a nationwide, questionnaire-based survey, the current practice of BP measurement and associated BP values in German medical practices.
Material And Methods: A nationwide survey in German medical practices was performed in the period from 10 May 2021 to 15 August 2021.
This study assessed whether a single pill combination (SPC) is associated with lower direct healthcare costs. Anonymized claims data of patients ≥18 years treated with drugs for cardiovascular (CV)-related diseases either as a single pill combination or multi-pill combination (follow-up to 1 year) were evaluated. After propensity score matching, 59,336 out of 1,369,840 patients were analyzed.
View Article and Find Full Text PDFAim: Current guidelines for the treatment of arterial hypertension (AH) or cardiovascular (CV) prevention recommend combination drug treatments with single pill combinations (SPC) to improve adherence to treatment. We aimed to assess whether the SPC concept is clinically superior to multi pill combination (MPC) with identical drugs.
Methods And Results: In an explorative study, we analyzed anonymized claims data sets of patients treated with CV drugs for hypertension and/or CV disorders who were insured by the German AOK PLUS statutory health fund covering 01/07/2012-30/06/2018.