Motivation and personality factors of Generation Z high school students aspiring to study human medicine.

Background: A new generation of medical students, Generation Z (Gen Z), is becoming the predominant population in medical schools and will join the workforce in a few years' time. Medicine has undergone serious changes in high-income countries recently. Therefore, it is unclear how attractive the medical profession still is for high school students of Gen Z.

New mechanistic insights of integrin β1 in breast cancer bone colonization.

Bone metastasis is a frequent and life-threatening complication of breast cancer. The molecular mechanisms supporting the establishment of breast cancer cells in the skeleton are still not fully understood, which may be attributed to the lack of suitable models that interrogate interactions between human breast cancer cells and the bone microenvironment. Although it is well-known that integrins mediate adhesion of malignant cells to bone extracellular matrix, their role during bone colonization remains unclear.

Radiological pitfall: Siliconoma in internal mammary lymph node mimics breast cancer recurrence.

Siliconomas are rarely found in internal mammary lymph nodes in the context of ruptured, ipsilateral, silicone breast implants. However, they can sometimes cause a diagnostic dilemma, as in the presented case. We discuss the diagnostic pitfalls that can arise from misinterpreting a siliconoma for a metastatic lymph node, review the literature, and suggest appropriate diagnostic approaches.

Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly expresses EBNA3A with conserved CD8 T-cell epitopes.

Post-transplantation lymphoproliferative disorders (PTLD) arise in the immunosuppressed and are frequently Epstein-Barr virus (EBV) associated. The most common PTLD histological sub-type is diffuse large B-cell lymphoma (EBV+DLBCL-PTLD). Restoration of EBV-specific T-cell immunity can induce EBV+DLBCL-PTLD regression.