Publications by authors named "O R Baricordi"
Article Synopsis
- A new lab-on-a-chip technology called DEParray uses dielectrophoresis to manipulate single biological cells and objects, enabling detailed study and interaction.
- The platform features an array of electrodes creating over 10,000 DEP cages, allowing for precise movement and targeting of cells, and can carry out various functions like cell interaction and immunophenotyping.
- DEParray can quickly assess immune responses and cell characteristics in real-time with minimal cell quantities, making it a promising tool for discovering new cell interactions without prior knowledge of their properties.
Human leucocyte antigen-G (HLA-G) is a non-classical HLA class I molecule with an important role at the fetus-maternal interface, preventing fetus recognition and abortion. The role of HLA-G as an immune-modulatory and anti-inflammatory molecule has led to investigate its role in pathological conditions. In these years, HLA-G has been shown to have an important implication in inflammatory pathologies.
View Article and Find Full Text PDFIntroduction: Human leukocyte antigen-G (HLA-G), a nonclassical major histocompatibility complex class I antigen, plays a pivotal role in immune tolerance and a paradoxical role in cancers.
Aims: Our aims were to evaluate plasma soluble HLA-G (sHLA-G) concentrations and the 14-bp insertion/deletion polymorphism of the HLA-G gene in patients with papillary thyroid carcinoma (PTC) or Hashimoto's thyroiditis (HT) and to assess the possible association of these parameters with PTC aggressiveness.
Methods: Samples for the analysis of sHLA-G and +14/-14-bp HLA-G polymorphism were obtained from 121 patients with HT and 183 with PTC; 245 gender- and age-matched healthy subjects served as controls.