Publications by authors named "O Popovych"
The neurodegenerative progression of Parkinson's disease affects brain structure and function and, concomitantly, alters the topological properties of brain networks. The network alteration accompanied by motor impairment and the duration of the disease has not yet been clearly demonstrated in the disease progression. In this study, we aim to resolve this problem with a modeling approach using the reduced Jansen-Rit model applied to large-scale brain networks derived from cross-sectional MRI data.
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- - The study investigates how the balance between excitation and inhibition in brain cortex microcircuits changes during adolescence, a critical period for brain maturation.
- - Using advanced simulations and resting-state fMRI data from two large groups, researchers found an increase in inhibition in certain brain regions (association cortices) as adolescents age, while sensorimotor areas showed more stable excitation levels.
- - The findings suggest that there’s a consistent developmental pattern in the excitation-inhibition balance that can vary among individuals, providing a new computational method to study brain maturation at a personal level.
Effective connectivity (EC) refers to directional or causal influences between interacting neuronal populations or brain regions and can be estimated from functional magnetic resonance imaging (fMRI) data via dynamic causal modeling (DCM). In contrast to functional connectivity, the impact of data processing varieties on DCM estimates of task-evoked EC has hardly ever been addressed. We therefore investigated how task-evoked EC is affected by choices made for data processing.
View Article and Find Full Text PDFThe 2023 European Respiratory Society Congress took place on a hybrid platform, with participants joining online and in-person in Milan, Italy. The congress welcomed over 20 000 attendees, bringing together exciting updates in respiratory science and medicine from around the world. In this article, early career members of Assembly 10 (Respiratory Infections) summarise a selection of sessions across a broad range of topics, including presentations on bronchiectasis, nontuberculous mycobacteria, tuberculosis, cystic fibrosis and coronavirus disease 2019.
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- * A 51-year-old woman experienced an expanding painless lump in her breast, which was eventually identified as a giant ruptured calcified oil cyst, following a long history of stable presence after a car accident.
- * Clinicians should consider oil cyst rupture as a possible diagnosis for expanding breast lumps; diagnostic mammograms are critical for identifying benign characteristics of these cysts.