Publications by authors named "O Polo"
Article Synopsis
- Restless legs syndrome (RLS) affects nearly 10% of older adults, but many face delays in diagnosis and treatment.
- A large-scale genetic study identified 164 risk loci for RLS, enhancing our understanding of its genetic basis and showing similarities in genetic predispositions between sexes.
- Findings suggest potential drug targets, a relationship between RLS and diabetes, and highlight the effectiveness of machine learning in predicting RLS risk using genetic and other data.
The post-viral fatigue syndromes long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have multiple, potentially overlapping, pathological processes. These include persisting reservoirs of virus, e.g.
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- - The study aimed to explore the relationship between blood pressure increases during menopause, sleep-disordered breathing, and the menopause itself, with a focus on identifying new markers to predict hypertension.
- - Sixty-four premenopausal women were observed over 10 years, with various assessments including polysomnography and hormone measurements, but key variables like apnea-hypopnea index showed no significant impact on blood pressure changes.
- - Results indicated that an increase in morning blood pressure was linked to higher body mass index, while evening blood pressure rises were associated with sleep-related breathing issues; hormone therapy users experienced lower apnea-hypopnea indices at the start, but effects on blood pressure were minimal overall.
Aims: The prevalence of cardiovascular diseases increases in women after menopause. The aim of the study was to determine the impact of conventional cardiovascular risk factors such as age, blood pressure, smoking, cholesterol, obesity, and glucose balance, but also menopausal state and sleep-disordered breathing on vascular impairment during menopausal transition.
Methods: 89 women initiated the study and 74 of them participated in the 10-year follow-up.
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic disease considered to be triggered by viral infections in a majority of cases. Symptoms overlap largely with those of post-acute sequelae of COVID-19/long-COVID implying common pathogenetic mechanisms. SARS-CoV-2 infection is risk factor for sustained latent virus reactivation that may account for the symptoms of post-viral fatigue syndromes.
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