Publications by authors named "O Planz"
Special Issue "The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation 2.0".
Int J Mol Sci
September 2024
Toll-like receptors (TLRs) are key players in the innate immune system, in host' first-line defense against pathogens [...
View Article and Find Full Text PDFRegulatory T cells (Tregs) play a crucial and complex role in balancing the immune response to viral infection. Primarily, they serve to regulate the immune response by limiting the expression of proinflammatory cytokines, reducing inflammation in infected tissue, and limiting virus-specific T cell responses. But excessive activity of Tregs can also be detrimental and hinder the ability to effectively clear viral infection, leading to prolonged disease and potential worsening of disease severity.
View Article and Find Full Text PDFArticle Synopsis
- Host targeting antiviral drugs (HTA), like Zapnometinib (ZMN), target essential cellular mechanisms viruses need for replication, potentially making it harder for viruses to develop resistance.
- In experiments comparing ZMN with direct acting antivirals (DAAs) such as Remdesivir and Paxlovid, it was found that while the DAAs allowed the virus to adapt and develop resistance, ZMN maintained its effectiveness.
- Notable mutations linked to resistance were discovered in DAAs, but ZMN showed a strong capacity to inhibit viral replication, suggesting it could be effective against viruses that are partially resistant to DAAs.