Publications by authors named "O Picard"
Aims And Background: Matrix metalloproteinase-7 (MMP-7) and Syndecan-1 (SDC1) are involved in multiple functions during tumorigenesis. We aimed to evaluate the diagnostic and prognostic performance of these serum proteins, as potential biomarkers, in patients with pancreatic ductal adenocarcinoma (PDAC) and benign pancreatic cysts.
Methods: In this case-control study, patients with newly diagnosed PDAC (N = 121) were compared with the benign cyst (N = 66) and healthy control (N = 48) groups.
Article Synopsis
- - The increase in Crohn disease (CD) cases, especially with urbanization and globalization, is more related to environmental factors rather than genetics, suggesting changes in lifestyle impact gut health.
- - The SOURCE study examined diet, microbiome, and genetic expression among newly diagnosed CD patients and controls from rural and urban settings in China and Israel to uncover links between lifestyle changes and CD.
- - Findings reveal that time spent in urban environments alters gut bacteria and metabolites in rural residents, with specific dietary factors like coffee and vitamin D showing potential protective roles against CD-related changes.
Fermentation is an ancient practice of food preservation. Fermented vegetables are popular in Eastern European and Asian countries. They have received a growing interest in Western countries, where they are mainly manufactured at domestic and artisanal scales and poorly characterized.
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- A study investigated the effectiveness of adalimumab, an anti-TNFα monoclonal antibody, in ulcerative colitis (UC) patients, revealing that fewer UC patients continued treatment compared to those with Crohn's disease (CD).
- In a cohort of 50 UC patients, only 22% maintained treatment through the follow-up period, while 51% of 98 CD patients did.
- The loss of response to treatment was notably higher in UC patients, with 34% developing antibodies against adalimumab, although immunogenicity rates were similar between both patient groups.
Article Synopsis
- - Ustekinumab is a monoclonal antibody used to treat Crohn's disease, with about 50% of patients achieving clinical remission after one year; the study aimed to find predictors of response to this treatment by analyzing blood samples before initiation.
- - RNA from blood samples of 36 adults with Crohn's was sequenced, identifying 22 responders and 14 nonresponders, but no significant gene expression signature was found between the two groups after correcting for false discovery rates.
- - Despite the lack of major differences in gene expression, nonresponders showed an increased inflammatory response with certain cytokine and chemokine receptor pathways, suggesting that further research with a larger sample is needed for validation.