Publications by authors named "O Peyrony"
Article Synopsis
- The study analyzed the occurrence of multidrug-resistant (MDR) bacteria in solid cancer patients with bloodstream infections (BSIs) over 25 years, revealing a significant rise in MDR strains, especially ESBL-producing bacteria.
- Among 6,117 BSI episodes, Gram-negative bacilli (GNB) were the most prevalent, and 24.8% of patients received inappropriate empiric antibiotic treatment (IEAT), which correlated with higher mortality rates.
- Risk factors for MDR BSIs included prior antibiotic use, infections occurring during treatment, and specific infection sources, highlighting the need for improved risk assessment and careful antibiotic prescribing to enhance patient outcomes.
Background: This study aimed to describe documented infections associated with postinfusion fever after CAR T-cell therapy and to evaluate daily changes in vital signs, laboratory results, and the National Early Warning Score (NEWS) in patients with and without confirmed bacterial infections following fever onset, with the objective of assisting in antibiotic stewardship.
Methods: This was a retrospective, observational study including all consecutive adult patients who received CAR T-cell therapy. Documented infection in the first fever episode after infusion, and clinical and analytic trend comparison of patients with bacterial documented infections and those without documented infections, are described.
Corrigendum to "Safety and effectiveness of isavuconazole in real-life non-neu tropenic patients" [International Journal of Infectious Diseases 144 (2024) 107070].
Patricia Monzó-Gallo Carlos Lopera Ana M Badía-Tejero Marina Machado Julio García-Rodríguez Olivier Peyrony
Int J Infect Dis
September 2024
Article Synopsis
- The study focused on cytomegalovirus end-organ disease (CMV-EOD) in critically ill, immunocompromised patients across 18 ICUs in France, Israel, and Spain, analyzing clinical characteristics and patient outcomes from January 2010 to December 2021.
- A total of 185 patients were examined, with pneumonia being the most common form of CMV-EOD, affecting 62.2%, followed by gastrointestinal disease; the overall hospital mortality rate was strikingly high at 61.4%.
- Key factors linked to increased mortality included having hematologic malignancies, particularly with active graft-versus-host disease, experiencing CMV pneumonia, and low lymphocyte counts
Article Synopsis
- Researchers studied the rise of azole-resistant invasive aspergillosis in hematology patients in a Spanish hospital over the last 4 months, identifying 4 cases total, with 3 being azole-resistant.
- The diagnostic methods included fungal culture, antifungal susceptibility testing, and real-time PCR for detecting both Aspergillus species and azole resistance mutations like TR34/L98H.
- Findings showed that all azole-resistant cases had significant hematologic conditions and risk factors, indicating a pressing need for better monitoring and development of new antifungal treatments.