Publications by authors named "O Peulen"
Article Synopsis
- - Macroautophagy is a complex process that can lead to cell death, influenced by various cell types and stressors, while ferroptosis is a specific kind of cell death related to lipid damage and iron dependency.
- - Certain types of autophagy, like ferritinophagy and lipophagy, play a role in triggering ferroptotic cell death by degrading protective proteins, whereas others, such as reticulophagy, help protect cells from this damage.
- - The review seeks to clarify the relationship between autophagy and ferroptosis, focusing on defining terms, outlining key components, discussing experimental techniques, and providing interpretation guidelines for ongoing research.
Background: Pancreatic ductal adenocarcinoma is an aggressive cancer type with one of the lowest survival rates due to late diagnosis and the absence of effective treatments. A better understanding of PDAC biology will help researchers to discover the Achilles' heel of cancer cells. In that regard, our research team investigated the function of an emerging oncoprotein known as myoferlin.
View Article and Find Full Text PDFIn obesity, adipose tissue infiltrating macrophages acquire a unique pro-inflammatory polarization, thereby playing a key role in the development of chronic inflammation and Type 2 diabetes. Increased saturated fatty acids (SFAs) levels have been proposed to drive this specific polarization. Accordingly, we investigated the immunometabolic reprogramming in SFA-treated human macrophages.
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