Publications by authors named "O Perovic"
SUMMARYInfections due to spp. are among the most difficult to treat. Most are resistant to standard antibiotics, and there is difficulty in distinguishing colonizers from pathogens.
View Article and Find Full Text PDFSurveillance is essential in the fight against antimicrobial resistance (AMR), to monitor the extent of resistance, inform prevention, control measures, and evaluate intervention progress. Traditional surveillance methods based on phenotypic antimicrobial susceptibility data offer important but limited insights into resistance mechanisms, transmission networks, and spread patterns of resistant bacterial strains. Fortunately, genomic technologies are increasingly accessible and can overcome these limitations.
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- A study explores antibiotic resistance in raw retail pork meat, focusing on microbiological and genetic characteristics in Gauteng, South Africa, due to concerns over antibiotic overuse and misuse.
- Various methods like antibiotic susceptibility testing, whole-genome sequencing, and residue analysis were employed to assess the meat samples, which revealed minimal resistance but identified tetracycline resistance genes.
- The findings suggest that while antibiotic residues in the meat were within safe limits, the presence of resistance genes could have broader implications for environmental health and the ongoing antibiotic resistance crisis, highlighting the need for further research.
Antimicrobial resistance (AMR) is a significant global public health threat. This review presents the most recent in-depth review of the situation of the main AMR types in relation to the most commonly prescribed antibiotics in the World Health Organization (WHO) African Region. Underlying genes of resistance have been analyzed where possible.
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- The study focused on antibiotic resistance in micro-organisms from pigs and humans on a commercial farm in South Africa, comparing results from traditional methods and whole-genome sequencing (WGS).
- It found that pig isolates showed higher levels of antibiotic resistance and more diverse resistance genes compared to those from humans, with various bacterial pathovars identified at low frequencies.
- While a common sequence type complex (STc 10) was prevalent in both groups, the research revealed genetic diversity and differences in virulence and resistance profiles linked to their sources.