Publications by authors named "O Pashchenko"
Purpose: Allogeneic hematopoietic stem cell transplantation (HSCT) is an established therapy for many inborn errors of immunity (IEI). The indications for HSCT have expanded over the last decade. The study aimed to collect and analyze the data on HSCT activity in IEI in Russia.
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- * Results show that PWID receiving OAT at PCCs had significantly higher composite quality health indicator (QHI) scores than those treated at specialty addiction clinics, highlighting better healthcare service delivery in the primary care setting.
- * The analysis also indicates that participants with long-term OAT use experienced even better health outcomes, emphasizing the importance of sustained treatment for improving care quality among PWID with OUD.
Article Synopsis
- Patients with mutations in the RAG1 or RAG2 genes can develop conditions like Omenn syndrome or combined immunodeficiency, and around 60% of those treated with hematopoietic stem cell transplantation (HSCT) experienced significant health issues like infections, autoimmunity, or organ damage.
- The study involved a diverse patient group and found that survival rates were 77.5% at one year and 67.5% at four years post-transplant, with infections being the leading cause of death.
- Early HSCT (before age 3.5) showed better immune recovery, especially if patients had no pre-existing organ damage, highlighting the importance of timely treatment.
Infection with the Zika virus (ZIKV) is an ongoing problem especially as accurate, cost-effective testing remains unresolved. In addition, coinfection occurs with both the Dengue virus (DENV) and ZIKV which leads to cross-reactivity between the flaviviruses and can result in false positives and inaccurate testing. This supports the current need for a simple assay that can detect Zika antibodies sensitively that at the same time can differentiate between cross-reactive antibodies.
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