Does accelerated hypofractionated adjuvant whole-breast radiotherapy increase mammographic density or change mammographic features?

Objective: To compare mammographic features before and after accelerated hypofractionated adjuvant whole-breast radiotherapy (AWB-RT) and to evaluate possible appearance of modifications.

Methods: A retrospective review of 177 females before and after an AWB-RT treatment (follow-up ranging from 5 to 9 years) was performed by four radiologists focused in breast imaging who independently evaluated diffuse mammographic density patterns and reported on possible onset of focal alterations; modifications in density and fibrosis with parenchymal distortion were deemed as indicators of AWB-RT treatment impact in breast imaging.

Results: Prevalent mammographic density (D) patterns in the 177 females evaluated were according to the American College of Radiology-Breast Imaging Reporting and Data System (ACR-BIRADS): D1, fibroadipose density (score percentage from 55.

Hypofractionation and concomitant boost to deliver adjuvant whole-breast radiation in ductal carcinoma in situ (DCIS): a subgroup analysis of a prospective case series.

To report the four-year outcomes of accelerated hypofractionated whole-breast radiotherapy (WBRT) with a concomitant boost (CB) to the tumor bed in ductal carcinoma in situ (DCIS), we performed a subgroup analysis of 103 patients affected with DCIS within a cohort of 960 early breast cancer patients treated with breast conservation and hypofractionated WBRT. Prescription dose to the whole breast was 45 Gy (2.25 Gy/20 fractions) with an additional daily CB of 0.

Five-year results of a prospective case series of accelerated hypofractionated whole breast radiation with concomitant boost to the surgical bed after conserving surgery for early breast cancer.

Accelerated hypofractionation (HF) using larger dose per fraction, delivered in fewer fractions over a shorter overall treatment time, is presently a consistent possibility for adjuvant whole breast radiation (WBRT) after breast-conserving surgery for early breast cancer (EBC). Between 2005 and 2008, we submitted 375 consecutive patients to accelerated hypofractionated WBRT after breast-conserving surgery for EBC. The basic course of radiation consisted of 45 Gy in 20 fractions over 4 weeks to the whole breast (2.

[Recurrent pancreatitis in Caroli's disease. Treatment by endoscopic sphincterotomy].

''Pure'' Caroli's disease is rarely observed, usually presenting with symptoms of cholangitis: cases of pancreatitis seem most infrequent in the literature. A case of recurrent pancreatitis in Caroli's disease associated with renal policystic disease is presented: the rareness of this manifestation is stressed and the possible pathogenetic hypotheses are discussed, as well as indications for the selected treatment by endoscopic sphincterotomy.

[A rare form of intestinal perforation: adenocarcinoma of the ileum. Presentation of a clinical case].

Ileal carcinoma is not frequent and its diagnosis is preoperatively quite difficult. The surgical approach often depends more on the on table situation than on a precise therapeutic protocol. The histological result is sometimes a real negative surprise and the five year survival of patients is similar to those operated for colonic carcinoma at the same stage.