[Clinical significance of cytokine level and T-cell lymphocyte response to B and C hepatic viral antigens in patients with type C and B+C hepatitis receiving antiviral therapy].

The authors studied the levels of cytokines (interleukin (IL)-1, IL-2, IL-4, IL-6, and interferon-gamma (IFN-gamma)) and cell response to HBV and HCV in the dynamics in patients with acute mixed hepatitis (B+C) who recovered or became chronically ill, as well as before and after treatment of hepatitis C. Patients who later recovered had high levels of IL-2 and IFN-gamma during the acute phase of the disease, and displayed T-lymphocyte sensitization to HbeAg, Hbcore Ag, and the non-structural protein HCV NS3. A significant elevation of IL-2 level and, especially, IFN-gamma level, as well as the appearance of T-lymphocyte response to HCV NS3, HCVcore Ag, and HCV NS4 was observed during antiviral therapy.

[Assessment of the values of immune response mediators in patients with acute hepatitis C receiving combined antiviral therapy].

The spectrum ofcytokines was studied in 32 patients with acute hepatitis C (AHC) on combined antiviral therapy (A VT) with realdiron plus ribavirin and in 30 patients with acute HCVinfection on basic therapy (control group). The content of immune response mediators in blood serum was measured by immune enzyme assay using test systems produced by Proteinovy Konntur (Saint Petersburg). AHC patients on A VT displayed a more prominent decrease in the levels of interleukins (IL-1beta, IL-6), tumor necrosis factor-alpha (TNF-alpha) vs.

[Topical problems of health protection in childhood and juvenile age in relation to forming cadre workers' labor longevity].

Complex investigations of worker-training process have revealed that priority within the process of choosing professon and vocational training is not given to hygienic problems concerning health of workers to be. The main stages of training do not have a common hygienic goal of improving health of workers to be and making their professional work more reliable. The authors substantiate the necessity for creating a common vocational training system based upon system analysis principles and providing for the consistent maintenance and improvement of students' health throughout the training process, including such stages as vocational guidance, vocational selection and training, to prolong professional longevity of qualified workers.