Development of a Drawing Application to Evaluate Hand and Wrist Function: A Pilot Study.

Introduction: We developed a custom digital drawing application to assess hand function. We conducted an initial validation study of this technique to (1) assess which drawing features are associated with hand function, (2) differentiate patients from control subjects for both dominant and nondominant hands, and (3) assess the correlation of drawing features with previously validated patient-reported outcome measures (PROMs).

Methods: In this prospective study, participants were asked to draw shapes on an Apple iPad with a digital pen using a custom app.

Associations of Lipid-Lowering Drugs With Blood Pressure and Fasting Glucose: A Mendelian Randomization Study.

Background: Observational studies have linked LDL-C (low-density lipoprotein-cholesterol)-lowering drugs with lower blood pressure (BP) and higher fasting glucose, but the causality remains unclear. We conducted a drug target Mendelian randomization study to assess the causal associations of genetically proxied inhibition of HMGCR (3-hydroxy-3-methylglutaryl coenzyme A reductase), PCSK9 (proprotein convertase subtilisin/kexin type 9), and NPC1L1 (Niemann-Pick C1-Like 1) with BP and fasting glucose.

Methods: Single-nucleotide polymorphisms in , , and associated with LDL-C in a genome-wide association study meta-analysis from the Global Lipid Genetics Consortium (173 082 European individuals) were used to proxy LDL-C-lowering drug targets.

Carbon dots induce endoplasmic reticulum stress-mediated lipid dysregulation and embryonic developmental toxicity in zebrafish.

Carbon dots (CDs) are widely utilized due to their exceptional physical and chemical properties. Nevertheless, there is a paucity of research examining the potential toxicity of carbon dots to human health, particularly with regard to developmental toxicity. The present study demonstrated that exposure to CDs resulted in increased mortality and malformations in zebrafish embryos.

Associations between brain imaging-derived phenotypes and cognitive functions.

We aimed to evaluate the potential causal relationship between brain imaging-derived phenotypes and cognitive functions via Mendelian randomization analyses. Genetic instruments for 470 brain imaging-derived phenotypes were selected from a genome-wide association study based on the UK Biobank (n = 33,224). Statistics for cognitive functions were obtained from the genome-wide association study based on the UK Biobank.