Publications by authors named "O P Riabchikov"

The comparative histological and morphometric analysis of the bronchial structures of human fetal lungs was performed. Fetal lungs were taken from pregnant women living in radionuclide polluted zones (Novozibcov, Bryansk region) or in control regions (Moscow) in different periods after Chernobyl accident. Relative areas of the bronchial epithelial tubes and mesenchyme, quantity of bronchial branches and buds (end sections) of epithelial tubes on cut area unit were determined.

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The liver, thymus, spleen, lymph nodes, palatine and pharyngeal tonsils, appendix and Peyer's patch were studied by morphological and immune methods in more than 100 human embryos of 3 to 34 weeks of development. The order of some organs development in the immune system is established. Key periods in the development of the thymus (5-12 weeks) and 18 weeks when peripheral organs enter the immune system are specified.

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The effect of human fetal tissues (hypothalamic, liver, spleen, adrenal, ovarian, testicle, uterine, prostatic, gut, placental cells) collected from the fetuses at the 16-22 weeks of prenatal development, on the cytological structure of the thymus of 2-years old CBA mice in 7, 14, 42 and 64 days after start of treatment has been studied using morphological and immunological methods. The data obtained suggest that the implantation of human fetal tissues does not stop totally, but postponed age involution of thymus.

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The literature information and the authors's data are presented on the lability of human fetus thymus changes under extremal conditions. In particular, the source of the thymus development is discussed determining its morphogenetic potencies, the sequences of its endocrine and lymphocytopoietic function appearance. Lymphocytes composition and kinetics of their quantity in the process of fetus development and thymus response to the unfavourable conditions of the mother are presented.

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