Publications by authors named "O P Noronha"
Article Synopsis
- The study aimed to evaluate the effectiveness of orbital lesion diagnoses by comparing findings from external radiologists to those from a specialized in-house radiologist, correlating these with final histopathological results.
- A retrospective review of 40 patients' imaging over 7 years showed a significant difference in accuracy, with the in-house radiologist achieving a 95% accuracy rate, compared to just 50% for extramural radiologists.
- The in-house radiologist also demonstrated much higher sensitivity and positive predictive values for both benign (93.31% sensitivity) and malignant lesions (95.24% sensitivity), indicating that specialized training improves diagnostic performance.
Purpose: Ethambutol (EMB) is one of the first-line drugs used for treating tuberculosis. Vision loss due to optic nerve toxicity is a well-known potential side effect of the drug. Our aim was to evaluate the clinical features and visual outcomes of patients with EMB optic neuropathy (EON).
View Article and Find Full Text PDFTo date, no neurodegenerative diseases (NDDs) have cures, and the underlying mechanism of their pathogenesis is undetermined. As miRNAs extensively regulate all biological processes and are crucial regulators of healthy brain function, miRNAs differentially expressed in NDDs may provide insight into the factors that contribute to the emergence of protein inclusions and the propagation of deleterious cellular environments. A meta-analysis of miRNAs dysregulated in Alzheimer's disease, Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies and frontotemporal lobar degeneration (TDP43 variant) was performed to determine if diseases within a proteinopathy have distinct or shared mechanisms of action leading to neuronal death, and if proteinopathies can be classified on the basis of their miRNA profiles.
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