Publications by authors named "O P Mintser"
Point mutations at codon 600 of the BRAF oncogene are the most common alterations in cutaneous melanoma (CM). Assessment of BRAF status allows to personalize patient management, though the affordability of molecular testing is limited in some countries. This study aimed to develop a model for predicting alteration in BRAF based on routinely available clinical and histological data.
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- - Noncommunicable diseases (NCDs) are a significant health issue, and mitochondrial dysfunction (MD) plays a crucial role in their development and progression, although the causes of MD itself are still not fully understood.
- - The study emphasizes the need for a comprehensive understanding of how NCD risk factors contribute to MD, proposing a theoretical framework based on extensive research into their relationship.
- - Conclusions suggest that MD contributes to organ dysfunction and the overlap of various NCDs, calling for preventative measures that focus on identifying and addressing the underlying risk factors, with mitochondria being a key target for treatment.
Article Synopsis
- The study investigated mutation rates in cutaneous melanoma (CM) among the Ukrainian population, focusing on clinical and histopathological aspects.
- The research involved 299 primary CM cases analyzed through RT-PCR and found a mutation rate of 56.5%, with significant associations to younger age, specific anatomical sites, and histological types.
- The findings indicated that melanoma cases with mutations had higher mitotic rates and Breslow thickness, particularly linked to superficial spreading histology and greater depth of invasion.
Objective: The aim: Of this publication is to evaluate the results of EPEA in functionally healthy respondents and patients with NCDs to deepen fundamental knowledge of Systemic Medicine, increase the effectiveness of measures to prevent and treat NCDs by improving their diagnosis and prevention through the introduction of modern science-intensive technologies.
Patients And Methods: Materials and methods: 114 respondents were included in an open non-randomized controlled study. 66 сcomorbid patients (71% - men; median age - 61(43; 80) years) with verified Ischemic Heart Disease: functional class II-III angina pectoris were included in the Main Group.
Objective: The aim of the publication is to substantiate a conceptual system of views on the role of internal electromagnetic fields and the scientific feasibility of studying the direction of their possible use as a diagnostic indicator in the examination of patients with NCDs.
Patients And Methods: Materials and methods: The of the presented data was carried out during a search study of methods for the rapid assessment of valeological status, prenosological early diagnosis of NCDs, analysis of existing methods for studying the electromagnetic phenomena of the human body.
Results: Review: The authors systematized the existing technical capabilities and instrumental methods in the framework of systemic medicine.