Publications by authors named "O P Kurmi"
CAR-T cell therapy in developing countries: how long should we wait?
J Immunother Cancer
December 2024
Low- and middle-income countries (LMICs) face a significant burden of cancer prevalence and incidence. However, the survival rates for patients with cancer in these regions are notably lower than those in high-income countries, primarily due to late diagnosis and limited access to advanced treatments. Chimeric antigen receptor (CAR) T-cell therapy has demonstrated promising outcomes in certain terminally ill patients with cancer, yet access to this treatment remains limited in LMICs, including Nepal.
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- - The study focuses on non-fatal overdoses among homeless individuals, emphasizing that understanding risk factors can help prevent fatal overdoses.
- - Researchers analyzed electronic medical records of 1221 patients, finding that 16% (194 individuals) had experienced a non-fatal overdose, often involving multiple substances like heroin, paracetamol, and benzodiazepines.
- - Key risk factors identified include being female, white, aged 36-45, and having chronic physical or mental health issues, suggesting that targeted prevention strategies could reduce overdose rates, such as providing overdose awareness training and access to naloxone.
Introduction: The Nepal Family Cohort study uses a life course epidemiological approach to collect comprehensive data on children's and their parents' environmental, behavioural and metabolic risk factors. These factors can affect the overall development of children to adulthood and the onset of specific diseases. Among the many risk factors, exposure to air pollution and lifestyle factors during childhood may impact lung development and function, leading to the early onset of respiratory diseases.
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