Publications by authors named "O P Kalmykova"
Background: Orenburg Region is located in the South Urals, mostly in the steppe zone and is characterised by various landscapes suitable for many Chenopodiaceae. The species of Chenopodiaceae are present in all major plant communities (saline vegetation, steppes, on limestone, chalk and sand, and as degraded or ruderal communities). In the steppe zone, many native subshrubby species (, , ) playing a crucial role in semi-deserts (known as southern steppes in the recent Russian literature) located southwards of Orenburg Region are locally found, and several annuals (, spp.
View Article and Find Full Text PDFLong-term efficacy of lipoprotein apheresis and lomitapide in the treatment of homozygous familial hypercholesterolemia (HoFH): a cross-national retrospective survey.
Orphanet J Rare Dis
September 2021
Article Synopsis
- Homozygous familial hypercholesterolemia (HoFH) is a rare and severe condition that is difficult to treat, often requiring both lipid-lowering medications and lipoprotein apheresis (LA) for management.
- A study comparing two groups of HoFH patients treated with lomitapide and LA showed that lomitapide resulted in a greater reduction in LDL-C levels and a possibly lower cardiovascular event rate, despite the fact that treatment goals were not fully met for a large portion of patients in either group.
- The findings suggest that lomitapide may offer better LDL-C control compared to LA, but further research is necessary to determine its impact on overall cardiovascular risk.
The authors report the diagnosis and surgical treatment of 5 patients with dilated phase of hypertrophic cardiomyopathy (HCM). Features of these patients are progressive heart failure, double-level blood flow obstruction and the risk of apical aneurysms. Reconstructive remodeling surgery is a reasonable alternative to heart transplantation despite the existing risk.
View Article and Find Full Text PDFBackground And Aims: Homozygous familial hypercholesterolaemia (HoFH) is a rare inherited condition characterized by elevated plasma low-density lipoprotein-cholesterol (LDL-C) levels, severe, accelerated atherosclerosis and premature coronary heart disease. We evaluated cardiovascular complications in HoFH patients over extended follow-up and investigated their association with changes in cholesterol over time, as well as total cholesterol burden.
Methods: In this retrospective single-centre study, 53 patients (baseline mean ± standard deviation [SD], total cholesterol 15.
Background: We evaluated the effect of 45 days of rosuvastatin or pravastatin treatment on the distribution of HDL subfractions in HIV-1-infected individuals receiving boosted protease inhibitors (PIs) with cardiovascular risk.
Methods: The distribution of HDL subclasses by gradient gel electrophoresis was blindly assessed in 74 HIV-1-infected individuals receiving boosted PIs at baseline and at day 45 of statin treatment, and compared with the distribution obtained in 63 healthy normolipidemic individuals taken as controls.
Results: No significant modification appeared in HDL distribution between the two arms of statins for the HIV-1-infected individuals.